| Shop-CommIT . | Kiev |
| SID Venture Partners | |
| Sigma | Kharkiv |
| SignSine | |
| Silença Tech | |
| Silma Performance Marketing | |
| Silver Solutions | |
| Simon Kuznets Kharkiv National University of Economics | Kharkiv |
| Simplify | Kiev |
| Singree | Odessa |
| Site-ua.com | Kiev |
| SiteBuilding | Kiev |
| SITV | Sumy |
| SKELAR | |
| Skif ISP | Kiev |
| Skif-Service | Kiev |
| Skillers | Kiev |
| SkillsUp | |
| SkillUP | |
| Skirda.NET | Kiev |
| Skynix | |
| SkySoft.tech | |
| Skytel Service | Kiev |
| SkyUp Studio | Dnipropetrovsk |
| Skywell Software | Kiev |
| SMarket Software | Kiev |
| Smart Engineering Systems | Kiev |
| Smart Rockstars | |
| Smart-Ui | |
| Smartbox | |
| SmartCoworking | |
| SmartFarming | |
| Smartfin UA | |
| Smartline | Kiev |
| Smartphone | Kiev |
| Smiss Ltd | Kharkiv |
| SMRK | |
| SocialBoost | |
| Soft Engeneering | Kiev |
| soft Xpansion | Kiev |
| Soft навколо | Khmelnytskyi |
| Soft-pro | Kiev |
| SOFT.ua | |
| SoftBalance | Kiev |
| SoftBee | |
| SoftBees | |
| SoftConstruct | |
| Softelix | |
| Softfree | Kiev |
| Softinform | Kiev |