| Name | Region |
|---|---|
| Softket | Kiev |
| Softline | |
| SoftList | Kiev |
| SoftLoft | Kharkiv |
| Softonix | Lviv |
| Softproject | Kiev |
| SoftRize | |
| SoftSoul | Kiev |
| Software Expert | Kharkiv |
| Softwarenetic | |
| Softwarez | Kiev |
| Softwarium | Kiev |
| SoftWars | |
| Solar Digital | |
| Solead Software | |
| SolidBrain | |
| SoloWay Tech | |
| SolverLabs | Kiev |
| Sombra | |
| Sonettic | Kiev |
| Sorbsys | |
| SOURCE iT | |
| SourceX | |
| Soutsob | |
| Sovtes | |
| Space Cossacks | |
| Space Electric Thruster Systems | Dnipropetrovsk |
| Spark Mail Ltd | |
| Sparkle Design | Kiev |
| SPD Group | |
| SpdLoad | |
| Specsprite | |
| Spintech Software | Kharkiv |
| Spotium 360 | |
| SRGH | Kiev |
| SSA Group | Kiev |
| StableFlow | |
| StageM | |
| StartEra | |
| StartIT training center | |
| Startup Depot | Lviv |
| Startup Jedi | |
| Startup Network | |
| Startup-Center Sumy State University | |
| SteepHost DC | Kharkiv |
| Stella Electronic | Kiev |
| Stellum Tech | Kharkiv |
| STM-studio | Dnipropetrovsk |
| Stolnitsky Ideas | Kiev |
| StopVirus | Kiev |